Abstract：Objective To understand the epidemic characteristics of HFMD in Ninghai County, and to provide a basis for prevention and control of HFMD in the future.Methods Data of HFMD in Ninghai County from 2009 to 2018 were obtained from the Infectious Disease Report Information Management System and descriptive epidemiological methods were used for analysis.Nucleic acid was detected by RT-PCR on pharyngeal swabs and stool samples.Results From 2009 to 2018, 31 093 cases of HFMD were reported in Ninghai County, including 8 severe cases and 2 deaths, with the average annual incidence 483.25/100 000 and the fatality rate 0.006%. There were two peaks each year, the main peak from April to July,and the second peak from October to December.The incidence of the disease varied greatly among the towns and streets, the urban area and the junction area were high incidence areas.Children under 5 years old accounted for 88.70% of reported cases, with diaspora 58.55 %, and with more boys than girls.The dominant strains showed different trends in different years.Conclusion HFMD is with high incidence, low severity and low fatality in Ninghai County, and the incidence is high every other year.High incidence year is caused by new converted dominant epidemic strains, and low onset year is caused by dominant epidemic strains of last year.Children under 5 years old are the main prevention and control group.Enterovirus 71(EV71) is prevalent every 2 to 3 years, the coxsackievirus A16(CVA16) is prevalent every three years or so, and other enteroviruses(PE) have an increasing trend.
孔志芳,杨斌,章海斌,胡莉莉,张丹,陈伟,王帆,葛宝湘. 2009—2018年浙江省宁海县手足口病流行特征及病原学分析[J]. 中国医院统计, 2019, 26(5): 373-376.
Kong Zhifang, Yang bin, Zhang Haibin,Hu Lili, Zhang Dan, Chen Wei, Wang Fan, Ge Baoxiang.. Epidemiological characteristics and pathogenicity study of hand foot and mouth disease in Ninghai County of Zhejiang Province from 2009 to 2018. journal1, 2019, 26(5): 373-376.
［2］WANG Y，SUN L，XIAO W，et a1．Epidemiology and clinical characteristics of hand foot，and mouth disease in a Shenzhen sentinel hospital from 2009 to 2011［J］．BMC Infect Dis，2013，13(1)：539-543．
［8］MA E，LAM T，CHAN KC，et al．Changing epidemiology of hand，foot， and mouth disease in hong kong，20012009［J］． Jpn J Infect Dis，2010，63(6)：422-426．
［9］ONOZUKA D，HASHIZUME M．The influence of temperature and humidity on the incidence of hand，foot，and mouth disease in Japan［J］．Sci Total Environ，2011（410／411）：119-125．
［11］PODIN Y，GIAS EL，ONG F，et al．Sentinel surveillance for human Enterovirus 71 in Sarawak， Malaysia：Lessons from the first 7 years［J］．BMC Public Health，2006（6）：180．
［12］ANG LW，KOH BK，CHAN KP，et al．Epidemiology and control of hand， foot and mouth disease in Singapore，20012007［J］．Ann Acad Med Singap，2009，38(2)：106-112．
