Abstract：Objective To investigate the related factors affecting the occurrence of acute illness during root canal treatment. Methods Totally 500 patients who underwent root canal therapy in our hospital from January to January 2019 were enrolled. According to the patients′ EIAE condition, Univariate analysis and multivariate logistic regression analysis were used to analyze differences in age, gender, tooth position, sinus tract, total flushing dose, disinfecting drug, root filling method, and root filling and the influencing factors inducing the occurrence of acute illness during root canal treatment. Results EIAE occurred in 168 of the 500 patients, with an incidence of 33.6%. Univariate analysis found that EIAE patients had differences in sinus tract, total flushing dose, root filling method, and root filling (P<0.05), compared with non-EIAE patients. There was no difference in age, gender, tooth position and disinfection drug (P>0.05). Multivariate logistic regression analysis showed that the risk factors of EIAE were: no sinus tract, 2 mL of total drug washing and below, multiple root filling and overcharging. And the goodness of fit of this model indicated an outstanding fitting (AUC=0.917).Conclusion Thoroughly cleaning the root canal, improving the filling quality, and improving the disposable root canal treatment method can reduce the occurrence of EIAE.
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